This is a joke right? DI and osteoporosis? Next they'll say your socks cause diabetes.
Nolan Kiser
May 30, 2023 AT 03:50
Actually there's a real link. Chronic hypernatremia from untreated DI leads to increased bone resorption. The kidneys can't conserve water, so calcium gets dumped. It's not widely known but it's in the literature.
Alex Rose
May 30, 2023 AT 19:41
The pathophysiological cascade involves AVP receptor dysregulation, which alters RANKL/OPG ratio in osteoblasts, leading to accelerated osteoclastogenesis. Peer-reviewed studies from JCEM 2021 confirm this mechanism.
peter richardson
May 31, 2023 AT 15:55
So what? You think this changes anything for people who actually have this? Nobody cares about your textbook nonsense.
Rose Macaulay
May 31, 2023 AT 22:46
I have DI and I got osteoporosis at 42. No one ever told me there was a connection. I wish someone had.
Vasudha Menia
June 1, 2023 AT 18:37
You're not alone, Rose 💙 I was diagnosed with both at the same time and my endo didn't connect the dots either. It's so important to share this!
Bryan Heathcote
June 2, 2023 AT 04:08
Wait, so if you treat the DI properly, does that slow down bone loss? That's the real question.
John Dumproff
June 2, 2023 AT 09:40
Yes, absolutely. Proper hydration and desmopressin therapy can stabilize bone density over time. I've seen it in my practice. Early intervention is key.
Alanah Marie Cam
June 3, 2023 AT 00:41
This is a critical clinical insight that must be integrated into standard endocrine protocols. The morbidity implications are substantial.
Ellen Frida
June 3, 2023 AT 06:53
i think its all connected like the universe and your emotions and water and bones are all like vibes man like why do we even have bones anyway
Kirk Elifson
June 3, 2023 AT 13:56
America still has the best endocrinologists. Other countries just copy what we figured out decades ago.
Sabrina Aida
June 3, 2023 AT 19:14
This is just another way for Big Pharma to profit off vulnerable patients. Bone scans and desmopressin are expensive. Who benefits?
Snehal Ranjan
June 4, 2023 AT 07:49
In India, we have a long tradition of Ayurvedic management of polyuria and skeletal weakness, employing herbs such as Ashwagandha and Guggulu, which have been shown in preliminary studies to modulate calcium metabolism and renal concentrating ability, though more rigorous clinical trials are required to establish efficacy and safety profiles comparable to synthetic analogues.
Hudson Owen
June 5, 2023 AT 00:30
The interplay between antidiuretic hormone and bone remodeling is a fascinating area of endocrine physiology that warrants further multidisciplinary investigation.
Alanah Marie Cam
June 5, 2023 AT 07:07
I would like to respectfully suggest that all clinicians screen for bone density in patients with central DI, regardless of age or symptom duration.
Robert Burruss
June 5, 2023 AT 22:46
If we consider the metaphysical implications of water as a carrier of life-force, and bone as the structure that holds our physical form, then perhaps DI is not just a hormonal disorder, but a disruption in the soul's ability to retain essence.
Yaseen Muhammad
June 6, 2023 AT 00:26
The evidence is clear. Central DI increases fracture risk by 2.3-fold in longitudinal cohort studies. Screening with DEXA every two years is recommended for all patients.
Alanah Marie Cam
June 6, 2023 AT 12:58
Thank you, Yaseen. That's exactly the kind of data we need to push for policy changes.
Uttam Patel
May 29, 2023 AT 15:16Nolan Kiser
May 30, 2023 AT 03:50Alex Rose
May 30, 2023 AT 19:41peter richardson
May 31, 2023 AT 15:55Rose Macaulay
May 31, 2023 AT 22:46Vasudha Menia
June 1, 2023 AT 18:37Bryan Heathcote
June 2, 2023 AT 04:08John Dumproff
June 2, 2023 AT 09:40Alanah Marie Cam
June 3, 2023 AT 00:41Ellen Frida
June 3, 2023 AT 06:53Kirk Elifson
June 3, 2023 AT 13:56Sabrina Aida
June 3, 2023 AT 19:14Snehal Ranjan
June 4, 2023 AT 07:49Hudson Owen
June 5, 2023 AT 00:30Alanah Marie Cam
June 5, 2023 AT 07:07Robert Burruss
June 5, 2023 AT 22:46Yaseen Muhammad
June 6, 2023 AT 00:26Alanah Marie Cam
June 6, 2023 AT 12:58