The Connection Between Central Cranial Diabetes Insipidus and Osteoporosis

18 Comments

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  Uttam Patel

  May 29, 2023 AT 16:16
  This is a joke right? DI and osteoporosis? Next they'll say your socks cause diabetes.
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  Nolan Kiser

  May 30, 2023 AT 04:50
  Actually there's a real link. Chronic hypernatremia from untreated DI leads to increased bone resorption. The kidneys can't conserve water, so calcium gets dumped. It's not widely known but it's in the literature.
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  Alex Rose

  May 30, 2023 AT 20:41
  The pathophysiological cascade involves AVP receptor dysregulation, which alters RANKL/OPG ratio in osteoblasts, leading to accelerated osteoclastogenesis. Peer-reviewed studies from JCEM 2021 confirm this mechanism.
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  peter richardson

  May 31, 2023 AT 16:55
  So what? You think this changes anything for people who actually have this? Nobody cares about your textbook nonsense.
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  Rose Macaulay

  May 31, 2023 AT 23:46
  I have DI and I got osteoporosis at 42. No one ever told me there was a connection. I wish someone had.
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  Vasudha Menia

  June 1, 2023 AT 19:37
  You're not alone, Rose 💙 I was diagnosed with both at the same time and my endo didn't connect the dots either. It's so important to share this!
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  Bryan Heathcote

  June 2, 2023 AT 05:08
  Wait, so if you treat the DI properly, does that slow down bone loss? That's the real question.
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  John Dumproff

  June 2, 2023 AT 10:40
  Yes, absolutely. Proper hydration and desmopressin therapy can stabilize bone density over time. I've seen it in my practice. Early intervention is key.
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  Alanah Marie Cam

  June 3, 2023 AT 01:41
  This is a critical clinical insight that must be integrated into standard endocrine protocols. The morbidity implications are substantial.
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  Ellen Frida

  June 3, 2023 AT 07:53
  i think its all connected like the universe and your emotions and water and bones are all like vibes man like why do we even have bones anyway
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  Kirk Elifson

  June 3, 2023 AT 14:56
  America still has the best endocrinologists. Other countries just copy what we figured out decades ago.
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  Sabrina Aida

  June 3, 2023 AT 20:14
  This is just another way for Big Pharma to profit off vulnerable patients. Bone scans and desmopressin are expensive. Who benefits?
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  Snehal Ranjan

  June 4, 2023 AT 08:49
  In India, we have a long tradition of Ayurvedic management of polyuria and skeletal weakness, employing herbs such as Ashwagandha and Guggulu, which have been shown in preliminary studies to modulate calcium metabolism and renal concentrating ability, though more rigorous clinical trials are required to establish efficacy and safety profiles comparable to synthetic analogues.
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  Hudson Owen

  June 5, 2023 AT 01:30
  The interplay between antidiuretic hormone and bone remodeling is a fascinating area of endocrine physiology that warrants further multidisciplinary investigation.
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  Alanah Marie Cam

  June 5, 2023 AT 08:07
  I would like to respectfully suggest that all clinicians screen for bone density in patients with central DI, regardless of age or symptom duration.
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  Robert Burruss

  June 5, 2023 AT 23:46
  If we consider the metaphysical implications of water as a carrier of life-force, and bone as the structure that holds our physical form, then perhaps DI is not just a hormonal disorder, but a disruption in the soul's ability to retain essence.
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  Yaseen Muhammad

  June 6, 2023 AT 01:26
  The evidence is clear. Central DI increases fracture risk by 2.3-fold in longitudinal cohort studies. Screening with DEXA every two years is recommended for all patients.
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  Alanah Marie Cam

  June 6, 2023 AT 13:58
  Thank you, Yaseen. That's exactly the kind of data we need to push for policy changes.